Pazopanib is indicated for kidney and soft tissue cancer. Pazopanib is an inhibitor of multiple tyrosine kinases that is indicated for the treatment of advanced renal cell carcinoma. It inhibits vascular endothelial growth factor receptors 1, 2 and 3, platelet-derived growth factor receptors alpha and beta, fibroblast growth factor receptors 1 and 3, cytokine receptor (Kit), interleukin-2 receptor inducible T-cell kinase (Itk), leukocyte-specific protein tyrosine kinase (Lck), and transmembrane glycoprotein receptor tyrosine kinase (c-Fms).
This OEL/ADE monograph covers both pazopanib and pazopanib hcl (CAS RN 635702-64-6).
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.