Phentolamine is indicated for reversing dental anesthesia, for high blood pressure due to adrenal disorder. Although the mechanism of action is not fully understood, phentolamine mesylate accelerates reversal of soft-tissue local anesthesia used in dental procedures. With its short duration of alpha-adrenergic blocking activity, phentolamine mesylate results in vasodilatation when applied to vascular smooth muscle. Phentolamine mesylate is an antihypertensive agent, with direct but less marked effects on heart muscle and vasodilator effects on vascular smooth muscle.", "Please note, this OEL/ADE monograph also applies to phentolamine mesylate (CAS RN 65-28-1).
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Phentolamine, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.