OEL Fastrac Catalog

Please note, this OEL/ADE monograph also applies to Phentolamine mesylate (CAS RN 65-28-1) and Phentolamine hydrochloride (CAS RN 73-05-2). Phentolamine is indicated for reversing dental anesthesia, for high blood pressure due to adrenal disorder. Although the mechanism of action is not fully understood, phentolamine mesylate accelerates reversal of soft-tissue local anesthesia used in dental procedures. With its short duration of alpha-adrenergic blocking activity, phentolamine mesylate results in vasodilatation when applied to vascular smooth muscle. Phentolamine mesylate is an antihypertensive agent, with direct but less marked effects on heart muscle and vasodilator effects on vascular smooth muscle.", "Please note, this OEL/ADE monograph also applies to phentolamine mesylate (CAS RN 65-28-1).

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:

• The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
• A listing of all cited references utilized in the derivation of the OEL and ADE
• An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

• Fully documented. Over 20 pages in length, with calculations and cited references.
• Save time! Unsurpassed delivery with instant download.
• Save money. Similar documents cost 5-12 times as much.
• Stay current. Automatic notification of revisions.

How to order

To order an OEL/ADE monograph for Phentolamine, just click the ADD TO CART button.

HBEL

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