Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. Ponazuril is a triazine-based drug that acts to inhibit enzyme systems in protozoa and/or decreasing pyrimidine synthesis. It is specific for apicomplexan organisms because the action attacks the apicoplast organelle in protozoa. This action produces a specific effect as an antiprotozoal agent without affecting other organisms. Because ponazuril is a weak acid with high lipid solubility, it is able to cross the intact blood-brain barrier and enter the cerebrospinal fluid (CSF), most likely by passive diffusion.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Ponazuril, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.