Potassium bromide is a salt indicated for the treatment of epilepsy. It is used in veterinary medicine as a hypnotic and sedative in cattle, horses, sheep, and pigs. It is also used as an adjunct treatment of colic and tetany in horses and acetonemia in cattle. In dogs, potassium bromide is used as an anticonvulsant to treat seizure disorders. In addition to pharmaceutical use, potassium bromide is an active ingredient in two registered pesticide products with the US Environmental Protection Agency (EPA). Potassium bromide is an inorganic salt that dissociates into its potassium and bromide ions in aqueous solutions. The mechanism of action of bromide has not been clearly defined. It is proposed that bromide may aid in controlling seizures through hyperpolarization of neuronal cell membranes by preferential movement across gamma-amino butyric (GABA)- activated chloride channels, leading to stabilization and decreased sensitivity of epileptic foci.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Potassium Bromide, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.