Please note, this OEL monograph also applies to sodium cyanide (CAS RN 143-33-9), acetone cyanohydrin (CAS RN 75-86-5), and cyanide (CAS RN 57-12-5). Important, please not that the ADE only applies to potassium cyanide. Potassium cyanide is an unapproved homeopathic intended to relieve the symptoms of tongue ulcers. Cyanide reacts with the trivalent iron in cytochrome oxidase to give a relatively stable complex. This inhibits the enzyme and blocks the last step in oxidative phosphorylation. The result is a deficiency of mitochondrial ATP and cell death. Particularly sensitive tissues are those of the CNS and heart.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Potassium Cyanide, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.