Praziquantel is an anthelmintic indicated for the treatment of infections due to all species of Schistosoma and liver flukes. It is also indicated for the treatment of tapeworms in dogs and cats. Praziquantel induces a rapid contraction and spasm of schistosomes by a specific effect on the permeability of the cell membrane. The drug further causes vacuolization and disintegration of the schistosome tegument. It also causes paralysis in the worms’ muscles accompanied by a rapid calcium ion influx inside the schistosome. The worms are then either completely destroyed in the intestine or passed in the stool. It is mainly effective against adult schistosomes, with minimum effectiveness at 3-4-week-old juvenile schistosomes.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL monograph for this compound, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.