Please note, this OEL/ADE monograph also applies to propafenone hydrochloride (CAS RN 34183-22-7). Propafenone is a class 1C antiarrhythmic agent indicated in multiple cardiac conditions including atrial fibrillation and flutter, tachycardia (rapid heartbeat), and ventricular arrhythmias. Propafenone is a Class 1C antiarrhythmic agent which has local anesthetic effects and stabilizing action on myocardial membranes. It reduces the upstroke velocity (Phase 0) of the monophasic action potential, spontaneous automaticity, and the fast inward current carried by sodium ions in Purkinje fibers. It also prolongs effective refractory period and increases the diastolic excitability threshold.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Propafenone, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.