Pyrazinamide is indicated for the treatment of tuberculosis and tuberculosis in the presence of HIV infection. Pyrazinamide, the pyrazine analogue of nicotinamide, is an antitubercular agent. Pyrazinamide may be used to kill or stop bacterial growth, depending on the concentration and the susceptibility of the organism, although the exact mechanism is unknown. It diffuses into Mycobacterium tuberculosis where the enzyme pyrazinamidase converts pyrazinamide to the active form, pyrazinoic acid. Pyrazinoic acid slowly leaks out and is converted to the protonated conjugate acid, which is thought to diffuse easily back into the bacteria and accumulate. The net effect of accumulation of pyrazinoic acid occurs at acidic pH, an environment below that which is necessary for growth of M. tuberculosis.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Pyrazinamide, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.