Please note, this OEL/ADE monograph also applies to pyrimethamine tartrate (CAS RN 65703-46-0), pyrimethamine phosphate (CAS RN 7681-25-6), and pyrimethamine pamoate (CAS RN 85819-86-9). Pyrimethamine is a folic acid antagonist used as an antimalarial or in combination with a sulfonamide to treat toxoplasmosis infections. Pyrimethamine is an antiparasitic compound and folic acid antagonist that is highly selective against plasmodia, the parasitic protozoan causing malaria, and Toxoplasma gondii, the cause of toxoplasmosis. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purine and pyrimidines, which are essential for DNA synthesis and cell multiplication. Pyrimethamine is a slow-acting blood schizontocide, is possibly active against pre-erythrocytic forms of the malaria parasite, and inhibits sporozoite development in the mosquito vector.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Pyrimethamine, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.