Quercetin 3-O-glucopyranoside (also known as isoquercitrin and isoquercetin) is a quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. It belongs to the class of organic compounds known as flavonoid-3-o-glycosides. It is a quercetin O-glucoside, a tetrahydroxyflavone, a beta-D-glucoside and a monosaccharide derivative. It derives from a beta-D-glucose. Isolated from Lepisorus contortus, it exhibits antineoplastic activity and has been found to decrease the rate of polymerization and sickling of red blood cells. Isoquercetin has a role as an antineoplastic agent, a plant metabolite, a bone-density conservation agent, an osteogenesis regulator, an antioxidant, a histamine antagonist and an antipruritic drug. Isoquercetin has been used in clinical trials studying the treatment of kidney cancer, renal cell carcinoma, advanced renal cell carcinoma, venous thromboembolism (VTE) in pancreatic cancer, and venous thromboembolism (VTE) in colorectal cancer, among others. Isoquercitrin, in combination with masitinib, is under investigation in clinical trials for best supportive care in hospitalized patients with moderate and severe coronavirus disease 2019 (COVID-19).
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.