Reserpine is a naturally occurring alkaloid produced by several members of the genus Rauwolfia, a climbing shrub indigenous to southern and southeast Asia. The compound is used to lower blood pressure and reduce heart rate and as a tranquilizer and sedative. Reserpine also has been used as a tranquilizer and sedative in animal feeds. Reserpine binds tightly to storage vesicles in central and peripheral adrenergic neurons and the drug remains at such sites for prolonged periods of time. The storage vesicles are rendered dysfunctional as a result of their interaction with reserpine, and nerve endings lose their ability to concentrate and store norepinephrine and dopamine. A similar process occurs at storage sites for 5-hydroxytryptamine. Reserpine induced depletion of biogenic amines correlates with evidence of sympathetic dysfunction and antihypertensive effects.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL monograph for this compound, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.