Sodium bromide is an inorganic sodium salt indicated for use as an antiepileptic and sedative for the treatment of seizures in adult humans and in dogs. Sodium bromide has also been used in iodophor teat dip formulations to prevent mastitis. It is also used as a homeopathic treatment to relieve the symptoms of teeth grinding. The pharmacological and toxicological effects of bromide are related to the displacement of chloride in the blood and central nervous system, and iodide in the thyroid. Bromide causes secondary anion potentiation of gamma-aminobutyric acid (GABA)-activated chloride channels, producing a hyperpolarized post-synaptic membrane. GABA is an inhibitory neurotransmitter and its receptors are complexed with chloride channels.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Sodium Bromide, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.