Please note, this OEL/ADE monograph also applies to CAS RN 7440-23-5. Sodium chloride is indicated for multiple conditions including corneal edema, elective termination of pregnancy, heat stroke, low blood sodium, shock due to low volume, and nasal irritation. Sodium is the principle cation of extracellular fluid and chloride is the principle anion of extracellular fluid. Sodium content normally determines the volume of extracellular fluid. Sodium is important in the regulation of osmolarity, acid-base balance, and the membrane potential of cells.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.