Sodium Metabisulfite

Sodium metabisulfite (also known as disodium disulfite) is an inorganic sodium salt composed of sodium and disulfite ions in a 2 to 1 ratio. It has a role as a food antioxidant. Sodium metabisulfite is used in chemical processing to activate polymerization of acrylonitrile and in waste treatment to reduce chrome wastes. It is also used in fruit and vegetable processing as a bleach and preservative. In addition, it is used in photo processing as a preservative for thiosulfate fixing baths and as a reductant for reversal developing. It is also used in tanneries to accelerate the depilatory action of lime for unhairing hides. In the textile industry it is used as an antichlor following chlorine bleaching of cotton and following shrink-proofing of wool and as a mordant. It is also used in dye manufacture to inhibit oxidation of sensitive amine groups, to replace chlorine groups with the sulfite radical and as an aid in the formation of naphthylamine derivatives. Also, it is used in water treatment as an antichlor and in the manufacture of explosives and detergents.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

Sodium Metabisulfite

CAS Registry Number:
$679 USD


Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:

  • The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
  • A listing of all cited references utilized in the derivation of the OEL and ADE
  • An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

  • Fully documented. Over 20 pages in length, with calculations and cited references.
  • Save time! Unsurpassed delivery with instant download.
  • Save money. Similar documents cost 5-12 times as much.
  • Stay current. Automatic notification of revisions.

How to order

To order an OEL/ADE monograph for Sodium Metabisulfite, just click the ADD TO CART button.


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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.
  • K. Rosenthal
  • Director of Manufacturing