Sodium picosulfate is a laxative used to prepare the bowel for a colonoscopy. Citric acid and magnesium oxide react in solution to create magnesium oxide, an osmotic laxative that retains water in the gastrointestinal tract. Sodium picosulfate is hydrolyzed by colonic bacteria to bis-(p-hydroxy-phenyl)-pyridyl-2-methane, which stimulates colonic peristalsis by direct action on colonic mucosa. When administered together as a precolonoscopy preparation, the stimulant laxative and osmotic laxative effects of sodium picosulfate and magnesium citrate, respectively, produce a purgative effect and (with consumption of additional fluids) watery diarrhea.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Sodium Picosulfate, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.