Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. A synthetic cyclic 14-amino acid peptide, which is identical in structure and action to natural somatostatin, is available. Antineoplastic effects and potential uses of somatostatin on various tumors, including pituitary adenomas, gastroenteropancreatic neuroendocrine tumors (GEP-NETs), paragangliomas, carcinoids, breast cancers, malignant lymphoma, and small-cell lung cancers, have been extensively investigated. Somatostatin has been used in the clinical setting for the diagnosis of acromegaly and gastrointestinal (GI) tract tumors. Its analogs have been developed to achieve more favorable kinetics for efficient use in the management of acute conditions, such as esophageal varices. Somatostatin is approved in India and other countries for the treatments of acute, severe GI hemorrhage, resulting from gastric or duodenal ulcers, hemorrhagic gastritis and esophageal varices, for the treatment of intestinal, biliary and pancreatic fistulae, for symptomatic treatment of excessive secretion from endocrine tumors of the GI tract, for treatment of postoperative complications and as prophylaxis following pancreatic surgery and coadjuvant treatment in diabetic ketoacidosis.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Somatostatin, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.