Please note, this OEL/ADE monograph also applies to taltirelin hydrate (CAS RN 201677-75-0). Taltirelin hydrate is the orally administered form of taltirelin. Taltirelin, a thyrotropin releasing hormone analog, is indicated for the improvement of ataxia in spinocerebellar degeneration (SCD). Taltirelin is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects, and little development of tolerance following prolonged dosing (4). The stable TRH analog taltirelin, which has been shown to pass the blood–brain barrier and be more resistant to enzymatic degradation than TRH, produces supraspinal mediated antinociceptive effects, which are characterized by their modality specificity recruiting distinct descending monoaminergic pathways to exert analgesic effects on thermal and mechanical nociception (5- hydroxytryptaminergic and noradrenergic pathways, respectively) and independent of its effects on the motor system.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Taltirelin, just click the ADD TO CART button.
If you're wondering about HBEL, we have something for you.
Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.