Please note, this OEL/ADE monograph also applies to terbutaline 1-sulfate (CAS RN 1273567-75-1), terbutaline hemisulfate (CAS RN 23031-32-5), terbutaline sulfate monohydrate (CAS RN N/A), terbutaline hydrobromide (CAS RN N/A), and terbutaline hydrochloride (CAS RN 53144-56-2). Terbutaline is indicated for the prevention and treatment of asthma and bronchospasm associated with bronchitis and emphysema. Terbutaline sulfate is a beta-adrenergic agonist with preferential effects on beta(2)- adrenergic receptors exerting bronchodilating and smooth muscle relaxation effects. Its pharmacologic mechanism is due to the stimulation of adenyl cyclase resulting in increased intracellular level of cyclic AMP. Elevated cAMP triggers relaxation of bronchial smooth muscle and inhibition of release of inflammatory mediators.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Terbutaline, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.