OEL Fastrac Catalog

Please note, this OEL/ADE monograph also applies to thiethylperazine maleate (CAS RN 1179-69-7), thiethylperazine malate (CAS RN 52239-63-1), and thiethylperazine dihydrochloride (CAS RN Not Available). Thiethylperazine is a piperazine phenothiazine derivative and a dopamine antagonist used as an antiemetic (1). Thiethylperazine is an atypical antipsychotic agent. Thiethylperazine is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. Thiethylperazine has been used in the management (but not the prevention) of vertigo or motion sickness. Thiethylperazine is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. The treatment of obsessive-compulsive disorder and severe behavioral disorders in autism is under investigation.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:

• The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
• A listing of all cited references utilized in the derivation of the OEL and ADE
• An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

• Fully documented. Over 20 pages in length, with calculations and cited references.
• Save time! Unsurpassed delivery with instant download.
• Save money. Similar documents cost 5-12 times as much.
• Stay current. Automatic notification of revisions.

How to order

To order an OEL/ADE monograph for Thiethylperazine, just click the ADD TO CART button.

HBEL

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