L-tryptophan is an essential amino acid and is indicated for the adjunct treatment of depressive disorders (2, 3). It is given in combination with lithium in bipolar patients with mania or depression (2). L-tryptophan is useful in increasing serotonin (5-HT) production, promoting healthy sleep, managing pain tolerance, and managing weight. Tryptophan is critical for the production of proteins, enzymes, and muscle tissue (4, 5). It is also essential for the production of niacin, and the synthesis of the neurotransmitter serotonin and melatonin. During the catabolism of tryptophan, the first key intermediate is kynurenine, which undergoes deamination yielding kynurenic acid. Kynurenic acid and metabolites have been shown to have anti-excitotoxic and anticonvulsive effects.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL monograph for this compound, just click the ADD TO CART button.
If you're wondering about HBEL, we have something for you.
Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.