Potent Compound Corner

The Proper Use of Assigned Protection Factors and Maximum Use Concentrations

October 19, 2017

Under the Occupational Safety and Health Administration’s (OSHA) Respiratory Protection Standard (29 CFR 1910.134), APFs and MUCs are used in the proper selection of respiratory protection equipment for non-IDLH (immediately dangerous to life and health) atmospheres.

Employers must select respirators using Table 1.0: Assigned Protection Factors. They also must consider MUC’s before respirator selection. Selection of respirators should be based on the actual airborne contaminant level found in the workplace. Determining the actual airborne contaminant level typically requires industrial hygiene monitoring.

In addition, for the APFs and MUCs to be properly applied, all respirators must be fit-tested and used in accordance with all local and federal regulations. The APF/MUC will not be accurate for employees that are not clean shaven, have hair that interferes with the fit of a tight-fitting respirator, have a poor fitting respirator, or an improperly selected cartridge. Employees wearing tight-fitting respirators with facial hair that interferes with the fit is a common deficiency found during potent compound safety gap assessments.

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What is an occupational exposure limit and why are they important?

October 11, 2017

Here at Affygility Solutions, we often get asked the question, “I’m being told that I need to find out the OELs for all my active pharmaceutical ingredients, but I don’t even know why I need them. Can you help?”

What is an Occupational Exposure Limit (OEL)?

So let me explain: Occupational exposure limits (OELs) are defined as the time-weighted average concentration of a contaminant, measured in the employee’s breathing zone, that is considered to be safe for the majority of healthy workers, for an eight-hour work shift and a forty-hour work week, and entire working lifetime.

OELs are health-based values that are established by expert toxicologists reviewing existing published, peer-reviewed literature, and scientific databases. In addition, for new chemical entities (NCEs), it may be necessary to review pre-clinical and clinical data to determine the OEL. Based on the currently available information, the expert toxicologists formulate a conclusion on the level of exposure that the average worker can experience without adverse health effects.

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Welcome to Potent Compound Corner

October 9, 2017

We're excited to announce and welcome you, readers, to the newest Affygility (virtual) publication: Potent Comound Corner.

We'll invigorate your mind, help keep you clued in to the latest EHS topics and ideas, and hopefully amuse you once in awhile.

Stay tuned to this space and you can expect to find…

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Affygility's Potent Compound Corner is a collection of musings, investigations and explorations of timely, relevant topics in the fields of toxicology, pharmacology, EHS and more.

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