Potent Compound Corner

What is an occupational exposure limit and why are they important?

October 11, 2017

Here at Affygility Solutions, we often get asked the question, “I’m being told that I need to find out the OELs for all my active pharmaceutical ingredients, but I don’t even know why I need them. Can you help?”

What is an Occupational Exposure Limit (OEL)?

So let me explain: Occupational exposure limits (OELs) are defined as the time-weighted average concentration of a contaminant, measured in the employee’s breathing zone, that is considered to be safe for the majority of healthy workers, for an eight-hour work shift and a forty-hour work week, and entire working lifetime.

OELs are health-based values that are established by expert toxicologists reviewing existing published, peer-reviewed literature, and scientific databases. In addition, for new chemical entities (NCEs), it may be necessary to review pre-clinical and clinical data to determine the OEL. Based on the currently available information, the expert toxicologists formulate a conclusion on the level of exposure that the average worker can experience without adverse health effects.

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Welcome to Potent Compound Corner

October 9, 2017

We're excited to announce and welcome you, readers, to the newest Affygility (virtual) publication: Potent Comound Corner.

We'll invigorate your mind, help keep you clued in to the latest EHS topics and ideas, and hopefully amuse you once in awhile.

Stay tuned to this space and you can expect to find…

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Affygility's Potent Compound Corner is a collection of musings, investigations and explorations of timely, relevant topics in the fields of toxicology, pharmacology, EHS and more.

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